结构上有信息的静止状态有效连接性回顾了皮层层次结构
Matthew D Greaves1,2, Leonardo Novelli1,2, Adeel Razi1,2,3,4
1School of Psychological Sciences, Monash University, Clayton, Victoria, Australia.
bioRxiv : the preprint server for biology
|April 15, 2024
概括
这项研究使用一种新型模型将大脑解剖学 (结构连接) 与大脑通信 (有效连接) 整合在一起. 研究结果显示,解剖学限制了沟通,改善了对健康和疾病中的大脑功能的理解.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
- 脑部成像 脑部成像
背景情况:
- 神经元通信对大脑功能至关重要.
- 宏观结构连接和有效连接之间的关系仍然不清楚.
- 了解这种联系对于破译健康和疾病中的大脑功能至关重要.
研究的目的:
- 评估一个分层的经验贝叶斯模型,将结构连接整合到静止状态有效连接中.
- 确定结构性连接是否为宏观层面的有效连接提供了有用的约束.
- 增强对大脑功能整合的理解.
主要方法:
- 开发了一个分层的经验贝叶斯模型,将结构连接先验纳入一个动态的因果模型.
- 进行了in silico分析,以验证模型性能与基本真相和替代模型相比.
- 分析了经验性的静态fMRI数据,以检查结构和有效连接之间的关系.
主要成果:
- 该模型成功地恢复了地面真实有效的连接 in silico.
- 在经验数据中观察到结构和有效连接之间的积极,单调的关系.
- 互联网合差异反映了已知的单模-跨模层次结构,支持生物可信性.
结论:
- 整合结构连接可以提高有效连接的估计.
- 这些发现支持了这样一个假设:大脑解剖学限制了大脑的沟通.
- 这种综合方法提供了对大脑功能和功能障碍的更全面的了解.
更多相关视频
08:51Statistical Modelling of Cortical Connectivity Using Non-invasive Electroencephalograms
Published on: November 1, 2019
5.6K
08:36Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
Published on: March 21, 2019
7.3K
相关概念视频
Cerebrum: Anatomical Overview II
1.6K
Each cerebral hemisphere can be divided into three main regions. The outermost region, the cerebral cortex, is a thin layer (2 to 4 millimeters thick) made up of gray matter, consisting of neuron cell bodies, dendrites, glial cells, and blood vessels. The middle region, or white matter, is primarily composed of myelinated nerve fibers organized into three types of large tracts: association fibers, commissures, and projection fibers. Association fibers connect different areas within the same...
1.6K
Somatosensory, Motor, and Association Cortex
492
The somatosensory cortex in the parietal lobes is crucial for interpreting sensory data such as touch, temperature, and proprioception. The somatosensory cortex, situated in the parietal lobes, plays a vital role in interpreting sensory information like touch, temperature, and proprioception—awareness of body position. This specialized brain region features an organized structure wherein neurons at the top primarily process sensations originating from the lower body. In contrast, those at...
492
Storage
84
A schema is a mental framework that helps individuals organize and interpret information. Schemata, formed from previous experiences, influence how we process new information: how we encode it, the inferences we make, and how we retrieve it. For instance, a schema for what a typical classroom looks like might include desks, a teacher's desk, a whiteboard, and students in such an environment. This expectation helps us quickly understand and navigate new classrooms without needing to analyze...
84
Neural Circuits
1.2K
Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
1.2K
