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Updated: Jun 28, 2025

Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization
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Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization

Published on: July 27, 2021

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调整主要成分可以在混合种群的全基因组关联研究中诱导虚假关联

Kelsey E Grinde1, Brian L Browning2, Alexander P Reiner3,4

  • 1Department of Mathematics, Statistics, and Computer Science, Macalester College, Saint Paul, Minnesota, 55105, USA.

bioRxiv : the preprint server for biology
|April 15, 2024
PubMed
概括

对于全基因组关联研究 (GWAS) 的主要成分分析 (PCA) 在混合种群中可能存在问题. 后来的主要组件 (PCs) 可能会捕获本地基因组特征,从而导致偏见的结果和虚假的关联.

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