轴相互作用和行为的年龄依赖调节由基林G oligodendrocyte Ankyrin
Xiaoyun Ding1, Yu Wu1, Victoria Rodriguez2
1Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030.
bioRxiv : the preprint server for biology
|April 15, 2024
概括
脚手架蛋白AnkyrinG (AnkG),由双相情感障碍 (BD) 风险基因ANK3编码,对质细胞至关重要. 基细胞中AnkG的损失会破坏大脑功能和行为,这表明它在神经精神疾病中起着作用.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 细胞生物学 细胞生物学
背景情况:
- ANK3基因编码AnkyrinG (AnkG),这是一个支架蛋白质,对神经元功能至关重要,并与双相情感障碍 (BD) 有关.
- 虽然神经元AnkG在BD类表型中的作用已知,但在成熟的神经系统中质AnkG的功能仍然不清楚.
结论:
- 质AnkG对于在衰老过程中维持质相互作用至关重要.
- 在神经精神疾病中,Oligodendroglial AnkG扮演着以前未知的角色.
相关概念视频
Nervous Tissue: Myelin
2.6K
The myelin sheath is a multilayered lipid and protein covering that insulates the axon of a neuron, enhancing the speed of nerve impulse conduction. Axons without this sheath are referred to as unmyelinated. Two types of neuroglia, Schwann cells in the peripheral nervous system (PNS) and oligodendrocytes in the central nervous system (CNS) are responsible for producing myelin sheaths.
Schwann cells begin to form myelin sheaths around axons during fetal development. They wrap around a small...
Schwann cells begin to form myelin sheaths around axons during fetal development. They wrap around a small...
2.6K
Neurogenesis and Regeneration of Nervous Tissue
768
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
768
Glial Cells
87.1K
Overview
87.1K
Nervous Tissue: Glial Cells
2.9K
Glia, or neuroglia, are vital support cells that assist neurons in their functions. The term "glia" originates from the Greek word for "glue," reflecting their role in holding the nervous system together. These cells can be categorized into six types: four in the central nervous system (CNS) and two in the peripheral nervous system (PNS).
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial...
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial...
2.9K


