在脊髓损伤患者中,通过神经 afferent刺激急性抑制下肢:试点研究
Sarah Massey1,2, Sean Doherty1,2, Lynsey Duffell1,2
1Aspire Centre for Rehabilitation Engineering and Assistive Techonologies, University College London, London, UK.
Wearable technologies
|April 15, 2024
概括
在脊髓损伤 (SCI) 后,神经 afferent刺激 (SAS) 有效地减少下肢和性. 这种非药物方法提供了一种安全且潜在的低成本方法,以改善SCI患者的功能和生活质量.
科学领域:
- 神经科学是一个神经科学.
- 康复医学 康复医学 康复医学
- 生物医学工程 生物医学工程
背景情况:
- 脊髓损伤 (SCI) 经常导致下肢和,影响患者的功能和生活质量.
- 目前用于的药物治疗可能会导致诸如嗜睡和虚弱等不良影响.
- 电刺激是一种有希望的替代方案,可以在没有显著副作用的情况下控制性.
研究的目的:
- 评价神经 afferent刺激 (SAS) 在减少SCI患者下肢和的疗效.
- 为了比较表面电刺激与植入电极对SAS的影响.
- 评估有条件 (按需) 和无条件 (连续) SAS 协议.
主要方法:
- 研究SAS使用在背部生殖神经上的表面电极 (N=7) 和植入电极在神经根上的神经根 (N=2).
- SAS协议包括条件刺激 (由引发) 和无条件刺激 (持续).
- 测量了急性引起的的抑制,并分析了期间的四头肌电动图 (EMG) 活动.
主要成果:
- 条件和无条件SAS都成功地抑制了SCI患者的急性发作.
- 与对照组相比,在SAS的期间观察到四头肌EMG活动的统计学显著减少.
- SAS在减轻的严重程度和频率方面表现出显著的效果.
结论:
- 圣 afferent刺激 (SAS) 显示出作为一种安全,低成本的治疗选择,用于管理SCI后的急性和性.
- SAS可以提供一种有效的非药物干预措施,以改善SCI患者的功能结果.
- 植入的SAS电极可能会增强现有的十字神经刺激装置的功能.
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