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唾液中的宿主微生物组关联预测了COVID-19的严重程度
Hend Alqedari1,2, Khaled Altabtbaei3, Josh L Espinoza4
1Department of Public Health and Community Service, Tufts University School of Dental Medicine, 1 Kneeland Street, Boston, MA 02111, USA.
PNAS nexus
|April 15, 2024
概括
口腔微生物组和唾液细胞因子可以预测2019年冠状病毒病 (COVID-19) 严重程度. 唾液中的微生物多样性较低与更糟糕的COVID-19结果相关,这表明在疾病发病过程中发挥了作用.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
背景情况:
- 口腔微生物群影响宿主对病毒感染的免疫反应.
- 口腔微生物组,细胞因子和COVID-19病原体之间的相互作用仍然不清楚.
研究的目的:
- 研究不同COVID-19严重程度组的唾液微生物组组成和宿主免疫参数之间的关系.
- 探索口腔微生物组和唾液细胞因子对COVID-19状态和呼吸系统严重性的预测价值.
主要方法:
- 从80个人 (COVID-19患者和未感染的对照) 收集了唾液和血液样本.
- 使用16S rRNA基因测序来表征口腔微生物组.
- 通过多重分析量化唾液和血清细胞因子/化学因子.
主要成果:
- 唾液微生物α多样性与COVID-19严重程度有负相关性.
- 口服宿主免疫反应 (唾液细胞因子) 与全身反应 (血清细胞因子) 不同.
- 微生物组扰乱分析在预测COVID-19状态和严重程度方面最有效.
结论:
- 口腔微生物组和唾液细胞因子显示出作为COVID-19状态和严重程度的生物标志物的潜力.
- 研究结果表明,在COVID-19病变发生过程中,局部粘膜免疫抑制和全身性超炎症.
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