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Daniéla Oliveira Magro¹, Ligia Yukie Sassaki², Júlio Maria Fonseca Chebli³

¹Department of Surgery, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas 13083-970, São Paulo, Brazil.

World journal of gastroenterology

|April 15, 2024

概括

饮食通过表观遗传机制显著影响炎症性肠病 (IBD). 采用地中海饮食和增加纤维摄入量可以减少IBD爆发,特别是在克罗恩病中.

科学领域:

胃肠病学胃肠病学
营养科学营养科学
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.

背景情况:

饮食在炎症性肠病 (IBD) 发病过程中起着至关重要的作用,与遗传因素相互作用.
在IBD中,表观遗传修饰,如DNA甲基化,基因素修饰和微RNA受饮食的影响.
西方饮食缺乏纤维和微量营养素,可能会通过影响短链脂肪酸的产生来促进IBD的发展.

研究的目的:

评论饮食作为炎症性肠病的表观遗传因素的作用.
探索遗传学,肠道微生物群和IBD中的饮食之间的相互作用.
为IBD患者提供基于证据的饮食建议.

主要方法:

关于饮食和IBD的现有研究的文献综述和评论.
对由饮食影响的表观遗传机制 (DNA甲基化,基因素修饰,微RNA) 的分析.
来自像IOIBD这样的知名组织的饮食指南的综合.

主要成果:

西方饮食缺乏纤维和微量营养素,可能会导致IBD的发病.
地中海饮食和纤维摄入量与IBD爆发的减少有关,特别是在克罗恩病中.
对于克罗恩氏病和性结肠炎患者,有关食物摄入的具体IOIBD建议存在.

结论:

IBD是一种复杂,异质的疾病,受到饮食和表观遗传学的影响.
针对表观遗传通路和微生物群调节的饮食干预措施对IBD管理有希望.
进一步的研究是必要的,以充分理解饮食和微生物群在IBD的表观遗传影响.

关键词:

克罗恩氏病是什么克罗恩氏病是什么饮食饮食饮食饮食胃肠道的微生物群遗传学是一个遗传学.炎症性肠道疾病炎症性肠道疾病微RNAs是一种微RNA.

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