颗粒物对阻塞性睡眠呼吸暂停患者持续正气道压力坚持的影响
Kanokkarn Sunkonkit1,2, Nantaporn Tiyapun1, Warawut Chaiwong3
1Sleep Disorders Center, Center for Medical Excellence, Chiang Mai University, Chiang Mai, Thailand.
Journal of thoracic disease
|April 15, 2024
概括
空气污染,包括PM10和PM2.5,并没有影响阻塞性睡眠呼吸暂停 (OSA) 患者的持续正气道压力 (CPAP) 坚持. 这项研究发现空气质量和CPAP使用率之间没有显著的相关性.
科学领域:
- 环境健康 环境健康
- 睡眠医学 睡眠医学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 众所周知,空气污染,特别是细颗粒物 (PM10和PM2.5),会影响睡眠质量.
- 在阻塞性睡眠呼吸暂停 (OSA) 患者中,PM10和PM2.5对持续正气道压力 (CPAP) 坚持的直接影响仍未得到充分研究.
- 了解这种关系对于优化污染环境中的OSA管理至关重要.
研究的目的:
- 调查环境空气污染水平 (PM10和PM2.5) 与OSA患者中低CPAP坚持之间的相关性.
- 为了确定增加对颗粒物的暴露是否会影响CPAP设备使用的一致性.
- 为医疗保健提供者和患者提供基于证据的见解,了解影响CPAP治疗的环境因素.
主要方法:
- 从2016年8月到2022年5月,在泰国清迈进行了一项时间序列研究.
- 分析了2,686名OSA患者的839名CPAP合规记录的数据.
- 低CPAP坚持被定义为使用 <240分钟/晚上或 <70%的晚上/月. 用一个通用的线性混合模型 (GLMM) 来分析月平均PM10/PM2.5水平与CPAP坚持度较低之间的相关性,并对混因素进行调整.
主要成果:
- 在增加PM10水平和低CPAP坚持之间没有观察到统计学意义上的影响 (调整后RR=0.97;95%CI:0.87,1.09;P=0.624).
- 同样,较高的PM2.5水平对CPAP粘附率较低没有显著影响 (调整后RR=0.93;95%CI:0.81,1.08;P=0.350).
- 这些发现表明,在研究的OSA群体中,颗粒物度和CPAP坚持率之间没有明显的关系.
结论:
- 在被诊断患有阻塞性睡眠呼吸暂停的患者中,颗粒物 (PM10和PM2.5) 似乎不会影响CPAP的坚持.
- 在这种人群中,环境空气质量可能不是持续CPAP治疗的重要限制因素.
- 进一步的研究可以探索其他影响CPAP遵守的环境或患者特异性因素.
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