自组装的纳米颗粒来自Xie-Bai-San:隔离,表征和增强口服生物利用性
Wenlong Nie1, Yun Liu1, Jinshuai Lan1
1School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201210, People's Republic of China.
International journal of nanomedicine
|April 15, 2024
概括
传统中医药中的天然纳米粒子增强了活性化合物的口服生物可用性. 这项研究分离和描述了这些纳米粒子,揭示了它们在治疗效果中的关键作用.
科学领域:
- 药理学 药理学是指药理学的学科.
- 纳米技术纳米技术
- 传统中国医药 传统中国医药
背景情况:
- 天然纳米颗粒存在于中国传统医学 (TCM) 中.
- 这些纳米颗粒对活性化合物的口服生物可用性的影响仍然不清楚.
- 石白山 (Xie-Bai-San decoction,XBSD) 是用来研究这种现象的.
研究的目的:
- 从XBSD中分离和描述纳米粒子 (N-XBSD).
- 为了阐明N-XBSD的形成机制.
- 探索N-XBSD在提高活性化合物的生物可用性方面的潜力.
主要方法:
- 从XBSD中分离和描述纳米粒子,使用粒子大小,PDI和泽塔电位测量.
- 在N-XBSD中识别活性化合物.
- 通过FT-IR和HRMS分析纳米粒子形成机制.
- 在大鼠中使用UPLC-MS/MS进行药理动力学研究,将N-XBSD与免费药物进行比较.
主要成果:
- 成功分离了N-XBSD (104.53 nm的平均尺寸,PDI 0.27,泽塔电位 -5.14 mV).
- 在N-XBSD中发现了八种主要活性化合物,有证据表明,诸如库库卡胺B,mulberroside A和liquiritin等化合物之间存在自我组装和结合.
- 药物动力学分析显示Cmax,AUC和T1/2显著更高,N-XBSD中的活性化合物的清除速度较慢,与大鼠的自由药物相比.
结论:
- 由活性化合物的自我组装形成的N-XBSD主要含有XBSD的主要活性成分.
- N-XBSD显著提高了活性化合物的口服生物可用性.
- 天然纳米颗粒在TCM中,在它们的治疗效果中起着至关重要的作用.
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