单细胞可以预测千里亚结核病的老年患者的预后和成功治疗
Yusuke Shima1, Takahiro Masuda1, Nanako Miwa1
1Department of Respiratory Medicine, Kobe City Nishi-Kobe Medical Center, Kobe, Japan.
概括
单细胞计数和比率预测了千叶结核病 (MTB) 的结果. 较低的单细胞计数和较高的淋巴细胞-单细胞比率表明MTB患者的预后较差.
科学领域:
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
- 老年医学 老年医学
背景情况:
- 毫叶结核病 (MTB) 构成显著的死亡风险,特别是在老年人群中.
- 现有的MTB预后生物标志物缺乏全面的预测能力.
- 单细胞作为MTB的预后生物标志物的作用仍未得到充分研究.
研究的目的:
- 为了研究单细胞在患有千里亚结核病的患者的预后价值.
- 确定特定的单细胞相关生物标志物及其对MTB预后的预测能力.
- 评估单细胞计数与患者生存结果之间的关联.
主要方法:
- 来自52名MTB患者的临床数据的回顾性分析 (2013年4月 - 2021年10月).
- 评估生物标志物对3个月预后的预测能力,并确定截止值.
- 治疗开始后生存时间和纵向单细胞变化的比较.
主要成果:
- 较低的单细胞计数 (#M),较高的淋巴细胞-单细胞比率 (LMR) 和较差的表现状况与3个月死亡率有关.
- #M已成为MTB的独立预后因素.
- #M和LMR表现出高预测性表现 (AUC=0.86和0.85,分别).
结论:
- 诊断时的单细胞计数及其纵向变化是MTB预后的重要预测因素.
- #M (≤200细胞/μL) 和LMR (>2.5) 的特定值与较短的存活时间相关.
- 治疗后#M的快速增加表明,在最初低单细胞患者中,预后更好.
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