综合饮食抗氧化剂指数与美国成年人甲状腺功能之间的关联:NHANES 2007-2012
Junru Liu1, Xiaofeng Lu2, Jialu Song2
1Department of Endocrinology and Metabolism, Jinhua People's Hospital, Jinhua, Zhejiang, China.
Heliyon
|April 15, 2024
概括
通过综合饮食抗氧化剂指数 (CDAI) 测量较高的饮食抗氧化剂摄入量与较低的甲状腺激素水平有关 (T4). 这表明饮食在甲状腺功能调节中的潜在作用.
科学领域:
- 营养科学 营养科学
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 氧化应激可以损害甲状腺.
- 已知特定的抗氧化剂可以减轻这种损伤.
- 饮食中抗氧化剂摄入对甲状腺功能的整体影响尚不清楚.
研究的目的:
- 研究综合饮食抗氧化剂指数 (CDAI) 与甲状腺功能之间的关联.
- 在美国成年人代表性样本中分析这种关系.
主要方法:
- 利用了2007-2012年NHANES队列中的6860名受试者的数据.
- 采用加权线性回归和光滑曲线拟合来评估关联.
- 进行子组分析以探索变化.
主要成果:
- 较低的CDAI值与较高的血清自由T4 (FT4) 和总T4 (TT4) 水平相关.
- 在调整混因子 (FT4β = -0.003,p = 0.005;TT4β = -0.035,p < 0.001) 之后,这种负相关性仍然显著.
- 这一趋势在CDAI四分位数中是一致的 (趋势FT4的p = 0.014;趋势TT4的p = 0.003).
结论:
- 含有抗氧化剂较高的饮食,以较高的CDAI表示,与自由和总T4水平的降低有关.
- 需要进一步的研究来阐明这种观察到的关系背后的机制.
- 饮食模式可能在调节甲状腺激素水平方面发挥作用.
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