慢性变量压力导致小鼠的性特异性肠道微生物组改变
Dawson R Kropp1, Jennifer R Rainville1, Matthew E Glover1
1School of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
Brain, behavior, & immunity - health
|April 15, 2024
概括
慢性压力会改变雄性和雌性小鼠的肠道微生物组合,影响免疫信号传递. 这些发现表明与压力相关的疾病的潜在治疗点.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 微生物组研究 微生物组研究
背景情况:
- 压力显著影响精神和胃肠道疾病.
- 免疫系统和肠道微生物群相互影响,特别是在压力下.
研究的目的:
- 为了研究免疫信号和肠道微生物组合在男性和女性小鼠在变量压力范式下之间的顺序关系.
- 为了确定肠道微生物群和免疫系统对慢性压力的性别特异反应.
主要方法:
- 在小鼠中利用了可变压力范式,在多个时间点 (压力前,压力期间,压力后) 收集组织和便样本.
- 通过使用多重测定和通过16S rRNA amplicon测序分析肠道微生物组成,量化了血和大脑中的细胞因子.
主要成果:
- 经过28天的慢性变量压力后,观察到肠道微生物对压力的反应的性别差异,但在6天后没有.
- 在28天的压力后,在两种性别中都发现了 *Erysipelotrichaceae* 和 *Lactobacillaceae* 比例的显著变化,男性和女性的方向变化相反.
- 肠道微生物组的改变与与eosinophilic免疫活性相关的细胞因子的变化有关.
结论:
- 慢性压力会导致肠道微生物组的性别特异性变化,与免疫系统的变化有关.
- 这项研究强调了潜在的免疫机制,这些机制是压力诱导的肠道微生物组变化的基础.
- 确定了潜在的药物点和微生物物种,用于应对与压力相关的条件.
更多相关视频
09:37Chronic Stress Shifts Effort-Related Choice Behavior in a Y-Maze Barrier Task in Mice
Published on: August 13, 2020
11.2K
06:55An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
Published on: December 2, 2015
22.5K
相关概念视频
01:30Stress and Mental Health
149
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...
149
01:27Psychoneuroimmunology: Cardiovascular Disease
30
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
30