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Updated: Jun 28, 2025

Acquisition of Resting-State Functional Magnetic Resonance Imaging Data in the Rat
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Acquisition of Resting-State Functional Magnetic Resonance Imaging Data in the Rat

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德克斯梅德托米丁通过阻断超极化激活的阳离子电流,延长了小鼠的利多卡因静脉区域麻醉

Tongtong Zhang1, Xincheng Liao2, Yuzhi Chen3

  • 1Department of Anesthesiology, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, People's Republic of China.

Drug design, development and therapy
|April 15, 2024
PubMed
概括

德克斯梅德托米丁通过直接抑制高极化激活的循环核酸门 (HCN) 通道,延长了利多卡因静脉内区域麻醉 (IVRA) 的持续时间. 这种效应独立于α-2上腺素受体,揭示了麻醉增强的新机制.

关键词:
德克斯梅德米丁 (Dexmedetomidine) 是一种制剂.超极化激活的循环核酸门通道.静脉内区域麻醉 静脉内区域麻醉利多卡因 (Lidocaine) 是一种药物.

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