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(18) 在患有IPAH和CTEPH的患者中,用正子发射断层扫描摄取F-氧糖的摄取量

Celik Sumer¹, Gulfer Okumus¹, Emine Goknur Isik²

¹Department of Pulmonary Diseases Istanbul University Istanbul Faculty of Medicine Istanbul Turkey.

Pulmonary circulation

|April 15, 2024

概括

18-氧葡萄糖正子发射断层扫描 (18FDG-PET) 显示,肺动脉高血压 (PAH) 患者的葡萄糖代谢增加. 这种成像技术可以帮助诊断PAH,并通过与关键压力指标相关联来预测其严重程度.

科学领域:

核医学是一种核医学.
心脏病学心脏病学
放射学放射学是一门学科.

背景情况:

肺动脉高血压 (PAH) 涉及增加的新陈代谢,导致肺复血管化,血管收缩和光滑肌肉细胞增殖.
18-氧葡萄糖正子发射断层扫描 (18FDG-PET) 对葡萄糖代谢和炎症敏感,这表明它有可能用于非侵入性PAH诊断.

研究的目的:

研究PET/CT成像作为异常性肺动脉高血压 (IPAH) 和慢性血栓栓塞性肺高血压 (CTEPH) 的诊断工具的实用性.
为了评估与对照组相比,在IPAH和CTEPH患者的肺,肺动脉和右心室 (RV) 中的FDG吸收.

主要方法:

对17名患者 (10名IPAH,7名CTEPH) 和30名对照进行了PET/CT扫描.
分析了人口统计数据,肺部的FDG吸收,肺动脉,右心室 (RA) 和RV.
患者在基线和6个月治疗后接受了6分钟步行测试,亲BNP水平测量和右心脏导管治疗.

主要成果:

与对照组相比,IPAH和CTEPH患者在左肺,右肺,RA和RV中表现出明显更高的FDG吸收.
在RV FDG吸收和平均肺动脉压 (mPAP) 之间发现了正相关性.
在RAFDG吸收和右心房压力 (RAP) 之间观察到正相关性.

结论:

增加RV和RA的FDG吸收可以预测肺高血压的存在.
在RV和RA中FDG的吸收与mPAP和RAP相关,分别是PAH的关键预后指标.
需要进一步的研究来确定FDG PET成像是否可以用于诊断或预测肺高血压的预后.

关键词:

在CTEPH的基础上,IPAH IPAH 是一个定子发射断层扫描 (PET) 是一种定子发射断层扫描.右心脏导管装置的使用.

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