增殖性皮白血症呈现为围绕项圈和癌症的环状:一个病例报告
Valentin Vergier1,2,3, Katarzyna Czarny1,4, Jean-Jacques Brau5
1Department of Dentistry, Faculty of Health, Université Paris Cité, Montrouge, FRA.
Cureus
|April 15, 2024
概括
在牙 (gPVL) 上的增殖性性白血病 (PVL) 是积极的,难以早期诊断. 这种罕见的口腔病变具有转化为状细胞癌 (SCC) 的高风险.
科学领域:
- 口腔病理学 口腔病理学
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
背景情况:
- 扩散性性白血病 (PVL) 是一种具有高恶性转变率的口腔病变.
- 牙PVL (gPVL) 是最具侵略性的亚型,其特点是迅速进展和高癌症风险.
- 由于非特异性的初始表现和解剖病理发现,对gPVL的早期诊断具有挑战性.
研究的目的:
- 报告一个罕见的牙PVL (gPVL) 病例与快速恶性转变.
- 突出gPVL.L.的诊断困难和攻击性.
- 要强调需要改进的诊断方法和针对性治疗gPVL.
主要方法:
- 一个72岁的女性患者的病例报告显示了牙白色病变.
- 18个月的临床随访,包括两次活检.
- 组织病理学分析和gPVL的诊断,随后的进展到SCC.
主要成果:
- 患者的gPVL迅速扩展,并在18个月内转化为SCC.
- 最初的活检显示了状增生和乳头瘤,其中含有状成分.
- 尽管进行了外科切除,骨移植和放射治疗,但仍观察到gPVL和SCC的复发.
结论:
- 牙PVL是一种罕见的,积极的口腔病变,具有快速恶性转变为SCC的高风险.
- 由于非特异性的初始组织病理学和独特的临床表现,诊断挑战仍然存在.
- 对病因学,病理学和生物标志物的进一步研究对于及时诊断和gPVL的有效管理至关重要.
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