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综合分析揭示了脱氧核糖核酶1作为人类癌症潜在的预后和诊断生物标志物

Loai F Eletr¹, Sahar H Ibnouf², Tanzeel A Salih³

¹Computing and Bioinformatics, Faculty of Science, Port Said University, Port Said, EGY.

|April 15, 2024

概括

脱氧核糖酶1 (DNASE1) 基因表达在不同癌症中有所不同. 高DNASE1与脏清细胞癌 (KIRC) 的预后不佳相关,表明其作为生物标志物的潜力.

科学领域:

在瘤学瘤学.
遗传学是一个遗传学.
生物信息学是一种生物信息学.

背景情况:

脱氧核糖核酶1 (DNASE1) 涉及各种癌症和自身免疫性疾病,如全身性红性狼.
DNASE1在癌症发育和进展中的特定作用在很大程度上仍未得到研究.

研究的目的:

为了对DNASE1表达进行全面的泛癌分析.
探索DNASE1与各种癌症类型的免疫透和遗传改变的关联.
评估DNASE1作为特定癌的潜在生物标志物.

主要方法:

使用的生物信息学工具:瘤免疫估计资源 (TIMER),基因表达简介交互分析 (GEPIA),阿拉巴马大学伯明翰癌症数据分析门户网站 (UALCAN),卡普兰-梅尔绘图器和cBioPortal.
进行了泛癌分析,以评估DNASE1表达模式.
在脏清细胞癌 (KIRC) 和脏 papillary 细胞癌 (KIRP) 中使用公开数据集验证了DNASE1表达.

主要成果:

DNASE1在膀皮质癌 (BLCA),乳腺侵入性癌 (BRCA) 和头平细胞癌 (HNSC) 中表达高.
相反,DNASE1在脏清细胞癌 (KIRC),脏 papillary 细胞癌 (KIRP) 和甲状腺癌 (THCA) 中表达较低.
在KIRC和KIRP中,DNASE1表达与免疫细胞透相关,高DNASE1与KIRC和其他TCGA瘤的预后不佳有关.

结论:

DNASE1显示出作为KIRC的预后和诊断生物标志物的潜力.
DNASE1可以作为KIRP的诊断生物标志物.

关键词:

诊断生物标志物的生物标志物在此之前,Dnase1 脏状细胞癌细胞癌脏细胞癌细胞癌预后生物标志物预后生物标志物

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