在接受内镜鼻腔外科手术的异性CRS患者的嗅觉和生活质量
Miguel Soares Tepedino1,2,3, Richard Louis Voegels4, Rogério Pezato5
1Department of Otolaryngology, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
异性慢性鼻炎 (eCRS) 手术结合布德胺鼻灌显著改善了气味和生活质量. 这些好处在eCRS患者手术后至少持续了一年.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 过敏和免疫学 过敏和免疫学
- 鼻科 鼻科是指鼻科的专家.
背景情况:
- 慢性鼻炎 (CRS) 是一种普遍的炎症性疾病,具有重大公共卫生成本和对生活质量的影响.
- 嗅觉功能障碍在CRS中很常见,而对于eosinophilic CRS (eCRS) 的手术干预的有效性仍然是可变的.
- 有限的客观数据存在于budesonide灌后eCRS手术对嗅觉和生活质量的影响.
研究的目的:
- 分析手术前和手术后的嗅觉功能和CcRS患者的生命质量,这些患者正在接受手术和布索尼德鼻灌.
- 评估这种联合治疗方法的长期疗效.
主要方法:
- 一项前性,不受控制的研究,涉及患有eCRS的患者.
- 术前和术后的评估包括鼻腔内镜,生活质量的SNOT-22问卷,以及嗅觉的宾夕法尼亚大学气味识别测试 (UPSIT).
- 经过培训的检查员在基线和术后3个月,6个月和1年进行了标准化的评估.
主要成果:
- 包括20名ECRS患者 (13名男性,7名女性,年龄23-65岁),其中8例伴并发性喘病例.
- 3个月后观察到嗅觉显著改善 (UPSIT分数),在手术后6个月和1年持续 (p=0.0063).
- 生活质量 (SNOT-22分数) 在术后3个月显著改善,并维持到1年 (p=0.0005).
- 组织中乙酸盐度与手术后的SNOT-22/UPSIT得分之间没有发现显著的关联,尽管乙酸盐度较高与手术前UPSIT得分较低相关.
结论:
- 对于eCRS的手术干预,当遵循大容量布德塞尼德鼻灌时,可以有效控制这种情况.
- 结合治疗导致嗅觉功能和患者生活质量在至少一年内显著和持续改善.
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