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Updated: Jun 28, 2025

Characterization of Complex Systems Using the Design of Experiments Approach: Transient Protein Expression in Tobacco as a Case Study
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用小样本确定剂量研究中的3+3设计:陷和可能的补救措施

Cody Chiuzan1,2, Hakim-Moulay Dehbi3

  • 1Northwell Health, New Hyde Park, NY, USA.

Clinical trials (London, England)
|April 15, 2024
PubMed
概括

对于第一阶段临床试验,传统的3+3设计被基于模型的方法 (如CRM,键盘和BOIN) 超越. 这些替代方案在确定最大耐受剂量 (MTD) 方面提供了更高的准确性和效率.

关键词:
3+3算法就是一个算法.第一阶段的剂量检测研究模型辅助设计的设计.基于模型的设计.小样本的样本大小很小.

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