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Updated: Jun 28, 2025

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
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·希佩尔·林道瘤抑制剂控制脏瘤发生中的m6A依赖基因表达

Cheng Zhang1, Miaomiao Yu1, Austin J Hepperla2,3,4

  • 1Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

The Journal of clinical investigation
|April 15, 2024
PubMed
概括

在清细胞细胞癌 (ccRCC) 中,VHL损失通过影响METTL3/METTL14复合体形成来抑制N6-甲基氨酸 (m6A) 修饰. 这种VHL-m6A通路调节PIK3R3的稳定性,影响ccRCC瘤的生长.

关键词:
在瘤学瘤学.瘤抑制剂 瘤抑制剂

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