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Updated: Jun 28, 2025

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过度活跃的STAT5劫持T细胞受体信号,并驱动不成熟的T细胞急性淋巴细胞白血病

Tobias Suske1, Helena Sorger1, Gabriele Manhart2

  • 1Institute of Animal Breeding and Genetics and.

The Journal of clinical investigation
|April 15, 2024
PubMed
概括

通过劫持T细胞受体 (TCR) 路径,STAT5过度激活驱动T细胞急性淋巴细胞白血病 (T-ALL). 针对STAT5或TCR组件为T-ALL提供了新的治疗选择,特别是在耐药病例中.

关键词:
遗传学 遗传学 是一个血液学 血液学 血液学在白血病中,白血病.在T细胞发育过程中,T细胞受体受体的 T 细胞受体.

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