在晚期肝细胞癌中对阿特佐利祖马布加贝瓦齐祖马布的器官特异反应:一个多中心的回顾性研究
Jaekyung Cheon1, Sanghoon Jung2, Jung Sun Kim1
1Department of Medical Oncology, CHA Bundang Medical Center, CHA University, Seongnam, South Korea.
概括
阿特佐利祖马布/贝瓦齐祖马布组合疗法在晚期肝细胞癌 (HCC) 的肝脏内病变中显示出改善的反应,与抗编程死亡1 (PD-1) 单疗法不同. 在HCC患者中,这种组合可以克服肝脏的免疫耐受性微环境.
科学领域:
- 肝细胞癌研究 肝细胞癌研究
- 在瘤学中的免疫疗法.
- 临床试验分析
背景情况:
- 反编程死亡1 (PD-1) 单疗法在晚期肝细胞癌 (HCC) 的肝脏内病变中显示出有限的响应率.
- 晚期HCC的肝外病变对抗PD-1治疗的反应比肝内病变更好.
- 在晚期HCC中对阿特佐利祖马布/贝瓦齐祖马布的器官特异性反应在很大程度上仍未被探索.
研究的目的:
- 评估先进的HCC患者接受一线阿特佐利祖马布/贝瓦西祖马布治疗的器官特异性治疗反应.
- 为了比较atezolizumab/bevacizumab在晚期HCC中的肝内病变与肝外病变的疗效.
- 为了研究瘤大小对肝脏内病变对阿特佐利祖马布/贝瓦西祖马布的反应的影响.
主要方法:
- 追溯性,多中心,观察性研究设计.
- 包括患有Child-Pugh类A,可测量的病变和可用的串行成像的高级HCC患者.
- 分析了131名患者的数据,这些患者接受了第一线阿特佐利祖马布/贝瓦西祖马布治疗.
主要成果:
- 阿特佐利祖马布/贝瓦齐祖马布的整体客观响应率 (ORR) 为29.0%,无进展生存时间中位数为6.8个月.
- 特定器官的ORR为肝脏的27.8%,淋巴结的42.2%,肺部的29.1%,其他部位的21.0%.
- 随着体积的增加,肝脏内瘤反应率下降 (<5厘米的35.6%,≥5厘米的15.0%).
结论:
- 阿特佐利祖马布/贝瓦齐祖马布在肝脏内病变中表现出良好的反应,与晚期HCC的肝脏外病变相似.
- 这种组合疗法可以在先进的HCC中克服免疫耐受性肝脏微环境.
- 这些发现表明,阿特佐利祖马布/贝瓦齐祖马布在治疗晚期HCC的肝脏内疾病方面具有潜在的益处.
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