在中国使用抗糖尿病药物的时间趋势和区域差异,2015-2022年
Jieqiong Zhang1,2, Sen Xu1,2, Xingyu Liu1,2
1Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmacy, Xi'an Jiaotong University, Xi'an, China.
Diabetes, obesity & metabolism
|April 15, 2024
概括
在中国,非胰岛素抗糖尿病药物的使用从2015年至2022年显著增加,硫氨基质和比瓜尼德是最常见的. 新的药物类别出现了快速增长,但在使用方面仍然存在显著的区域差异.
科学领域:
- 药物经济学 药物经济学
- 公共卫生 公共卫生
- 内分泌学 在内分泌学.
背景情况:
- 糖尿病管理是中国日益严重的公共卫生问题.
- 非胰岛素抗糖尿病药物在治疗糖尿病方面发挥着至关重要的作用.
- 了解它们的采购趋势对于医疗保健规划至关重要.
研究的目的:
- 评估2015年至2022年间中国非胰岛素抗糖尿病药物的采购趋势.
- 分析这些药物的使用模式的区域差异.
主要方法:
- 对29种非胰岛素抗糖尿病药物的国家采购数据的分析,分为9个子组.
- 根据区域人口调整的每名患者定义日剂量 (DDDs) 的估计.
- 区域采购比例和差异的计算.
主要成果:
- 在2015年至2022年期间,每个患者的整体DDD从14.45增加到47.37.
- 硫基urea和biguanides仍然占主导地位,使用量显著增加.
- 新的药物类别 (DPP-4 抑制剂,SGLT-2 抑制剂,GLP-1 RAs) 呈现出快速增长 (>5000%的相对变化).
- 西南地区的采购相对变化最高,而南部地区的采购相对变化最低.
- 观察到显著的区域差异,比古安化物和 thiazolidinediones 显示分别是最低和最高的差异.
结论:
- 在中国,非胰岛素抗糖尿病药物的采购从2015年到2022年大幅增加.
- 硫氨酸urea和甲胺是最常用的药物类别,基于每名患者的DDD.
- 在采购较新的抗糖尿病药物方面出现了显著的增长.
- 在药物使用和模式方面发现了显著的区域差异.
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