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糖尿病足中多药耐药细菌感染的发生率:元分析

Shaoling Yang¹, Liye Hu¹, Yue Zhao²

¹Department of Endocrinology, The Bethune International Peace Hospital, Shijiazhuang, China.

International wound journal

|April 15, 2024

概括

多抗药性 (MDR) 细菌感染在糖尿病足 (DFU) 中非常普遍,影响超过50%的病例. 关键的危险因素包括周围血管疾病,神经病变和以前的抗生素使用.

科学领域:

传染性疾病传染性疾病
微生物学微生物学
公共卫生公共卫生

背景情况:

糖尿病足 (DFU) 是糖尿病的一个重要并发症,经常导致严重的感染.
多药耐药 (MDR) 细菌的增加对有效的DFU治疗和患者的治疗结果构成越来越大的威胁.
了解DFU中MDR感染的患病率和风险因素对于开发有针对性的治疗策略至关重要.

研究的目的:

为了确定从DFU中分离的MDR细菌的流行率.
在患有DFU的患者中识别与MDR细菌感染相关的风险因素.

主要方法:

进行了全面的元分析,搜索了多个数据库,直到2023年11月.
包括21项涉及4885名患者的研究,并分析了2633个MDR细菌分离物.
评估了临床变量来比较MDR和非MDR感染的DFU患者.

主要成果:

在DFU中,MDR细菌的总体患病率为50.86%.
更多的MDR阴性细菌 (32.84%) 比MDR阳性细菌 (GPB) (19.81%) 更多.
确定的主要危险因素包括周围血管疾病,神经病变,病,骨髓炎和先前暴露于抗生素.

结论:

DFU 呈现出多种耐药性细菌引起的感染的高患病率,需要紧急临床治疗.
主要的病原体是MDR阴性细菌,特别是大肠杆菌和MDR阳性细菌,特别是金黄色葡萄球菌.
识别和管理诸如血管疾病,神经病变和先前治疗等风险因素对于减轻DFU患者的MDR细菌感染至关重要.

关键词:

这种MDR细菌是MDR细菌.糖尿病人的足部.患病率的流行情况.有关风险因素的风险因素.

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