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立体特定的NANOG PEST稳定通过Pin1

Josephine C Ferreon1, Hai Minh Ta1, Hyosuk Yun2

  • 1Verna and Marrs McLean Department of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, Texas 77030, United States.

Biochemistry
|April 15, 2024
PubMed
概括

蛋白质异构酶Pin1稳定了NANOG,这是干细胞多能性的关键因素. 这项研究揭示了NANOG酸化如何增强Pin1结合,为癌症干细胞提供潜在的治疗点.

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