"COVID-19和慢性病毒性肝炎患者血小板的超结构变化"
Ayat SalahEldin Mohamed Hassan1, Sahar Samir Abdelmaksoud Abo Gaziah2, Hieba Gamal Ezzelregal Awad3
1Department of Electron Microscopy, Theodore Bilharz Research Institute, Giza, Egypt.
Ultrastructural pathology
|April 15, 2024
概括
COVID-19和慢性病毒性肝炎感染显著影响血小板,导致激活和亡变化. 血小板因子-4 (PF-4) 水平表明疾病的严重程度,与凝血标志物相关.
科学领域:
- 血液学 血液学 血液学
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- 凝血障碍是COVID-19的一个重要后果.
- 慢性病毒性肝炎感染通常会导致凝血因子缺陷,血小板缺陷和血小板功能障碍.
- 与SARS-CoV-2和慢性病毒性肝炎的双重感染是可信的,特别是在特有地区.
研究的目的:
- 为了研究COVID-19患者的血小板超结构变化.
- 量化血清中的血小板因子-4 (PF-4),费里丁,C反应蛋白 (CRP) 和D-二次体的水平.
- 评估同时存在的慢性病毒性肝炎对这些参数的影响.
主要方法:
- 对COVID-19患者 (n=60),COVID-19患有慢性病毒性肝炎患者 (n=20) 和健康对照组 (n=20) 的比较分析.
- 电子显微镜用于评估血小板的超结构形态.
- 血清生物化学试验用于PF-4,费里丁,CRP和D-二元量的量化.
主要成果:
- 在所有患者组中都观察到超结构性血小板激活.
- 慢性病毒性肝炎患者表现出血小板超结构性亡变化.
- 在中度至严重的COVID-19中显著增加PF-4水平 (P<0.001),预测截止值为17 ng/ml.
- PF-4与费里丁,CRP和D-二聚体 (P<0.001) 有正相关性,与血小板和颗粒数 (P<0.001) 有负相关性.
- 患有双重感染的患者表现出轻微的COVID-19症状,PF-4水平与轻微的COVID-19病例相似.
结论:
- 血小板激活和超结构性变化在COVID-19凝血病和慢性病毒性肝炎中至关重要.
- 升高的PF-4作为COVID-19严重程度的敏感生物标志物,与关键的炎症和凝血标志物相关.
- 双重病毒感染对血小板功能造成重大负担,强调需要警的凝血监测.
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