加拿大成年人中型肝炎流行情况的最新评估:元分析
Robert J Wong1,2, Grishma Hirode3, Jordan Feld3
1Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Palo Alto, California, USA.
Journal of viral hepatitis
|April 15, 2024
概括
在加拿大,估计有55万人患有慢性乙型肝炎 (CHB),35059人患有甲型肝炎三角病毒 (HDV). 出生在国外的人占这些病例的很大一部分,强调了有针对性的公共卫生战略的需要.
科学领域:
- 肝病学和传染病的研究
- 公共卫生和流行病学
- 移民 卫生 移民 卫生
背景情况:
- 在加拿大,外国出生的 (FB) 个人占慢性乙型肝炎 (CHB) 的成年人中很大一部分.
- 许多FB人的原籍国存在较高的CHB和型肝炎病毒 (HDV) 患病率.
- 低于最佳的认识和低的HDV测试率导致加拿大的诊断不足和不准确的流行率估计.
研究的目的:
- 评估加拿大的CHB和HDV的流行情况.
- 估计加拿大的CHB和HDV总人数.
- 确定在患有CHB和HDV的人群中FB人群的比例.
主要方法:
- 进行了全面的文献审查和对报告HBsAg血清流行率和抗HDV流行率的研究的元分析.
- 计算了CHB和HDV的特定国家和聚合流行率.
- 综合国家特定流行率估计与加拿大统计局2021年关于FB人口的数据来估计总数.
主要成果:
- 据估计,2021年加拿大约有0.550万 (95%CI:0.488-0.615) 人患有CHB,其中0.344万是FB.
- 在FB人群中,HDV的平均发病率为5.19%,主要来源于亚洲 (50%) 和非洲 (31%).
- 据估计,2021年加拿大约有35,059人 (95%CI:18,744-52,083) 患有HDV,包括FB和加拿大出生的个人.
结论:
- 在2021年,加拿大估计有0.550万个人生活在CHB和35,059生活在HDV.
- 在加拿大,出生在国外的个人占CHB病例的显著多数,占HDV病例的很大一部分.
- 调查结果强调了解决加拿大的FB人口健康需求的重要性,以有效控制加拿大的CHB和HDV.
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