早期结直肠癌患者的治疗模式与早期结直肠癌患者不同吗?
Oliver Waddell1,2, Yahsze Teo3, Nasya Thompson1
1Department of Surgery, University of Otago Christchurch, Christchurch, New Zealand.
Expert review of anticancer therapy
|April 15, 2024
概括
早发性结肠直肠癌患者接受更积极的治疗,包括化疗,但没有改善生存率. 这表明年轻患者治疗危害增加的可能性.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 临床研究 临床研究
背景情况:
- 早期结直肠癌 (EOCRC) 的发病率不断上升.
- 国际指南建议对EOCRC和晚发性结直肠癌 (LOCRC) 进行一致的治疗.
- 以前的研究表明,对于EOCRC来说,更积极的治疗没有生存益处.
研究的目的:
- 为了比较2和3阶段的治疗模式,EOCRC与LOCRC相比.
- 调查年轻结直肠癌患者护理方面的潜在差异.
主要方法:
- 追溯,基于人口的队列研究.
- 在新西兰坎特伯雷诊断的结直肠癌患者的分析 (2010-2021年).
- 在EOCRC (<50岁) 和LOCRC (60-74岁) 队列之间的治疗比较.
主要成果:
- EOCRC患者 (2期) 更有可能接受辅助化疗 (p<0.001).
- EOCRC患者 (2-3阶段) 更有可能接受多种药物治疗 (p<0.01).
- 在EOCRC中增加治疗强度与改善的生存率没有相关性.
结论:
- EOCRC患者接受更密集的治疗,特别是辅助化疗,没有生存优势.
- 有可能增加与治疗相关的危害,特别是在第二阶段.
- 临床医生在管理年轻结直肠癌患者时必须考虑治疗偏见和危害.
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