摄入2-化基他胺:约有2例死亡和1例自残事件
Salomé Riess1, Marjorie Chèze1, Aurelie Muckensturm1
1Laboratoire Toxlab, 7 rue Jacques Cartier, Paris 75018, France.
Journal of analytical toxicology
|April 15, 2024
概括
这项研究详细介绍了三起涉及2-化 (2-FDCK) 的案例,其中包括一起自残和两起法医死亡. 分析证实了生物样本中的2-FDCK及其代谢物,并观察到潜在的代谢到Deschloroketamine (DCK).
科学领域:
- 法医毒理学 法医毒理学
- 分析化学 分析化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 2-化 (2-FDCK) 是一种新兴的新型精神活性物质 (NPS),其结构与胺相关.
- 有限的法医文献存在于2-FDCK,特别是关于死亡的事故.
研究的目的:
- 在生物矩阵 (血液,尿液,头发) 中识别和量化2-FDCK及其主要代谢物.
- 调查2-FDCK在法医病例中的作用,包括自残和死亡.
主要方法:
- 生物流体和头发的分析使用液态染色学与联质谱学 (LC-MS/MS) 相结合.
- 使用气体染色学-质谱学 (GC-MS) 和超高性能液体染色学与二极管阵列检测 (UPLC-DAD) 分析扣押的产品.
主要成果:
- 在三例病例中的血液和头发样本中检测和量化了2-FDCK和代谢物 (nor-2-FDCK,dihydro-nor-2-FDCK,dihydro-2-FDCK).
- 在生物样本中也发现了脱甲基胺 (DCK);其在案例2中的存在可能是生物基质中2-FDCK代谢中DCK形成的首个报告案例.
结论:
- 这项研究在复杂的法医病例中提供了关于2-FDCK及其代谢物的关键分析数据.
- 这些发现强调了将2-FDCK纳入NPS相关事件的毒理学查的重要性.
- 2-FDCK到DCK的潜在代谢途径需要在法医毒理学中进一步调查.
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