T细胞子集和细胞因子是NSCLC中新辅助化疗免疫治疗反应的迹象
Ling Yi1, Ziwei Xu2, Tianyu Ma3
1Department of Central Laboratory, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital Medical University, Beijing, China.
Cancer immunology, immunotherapy : CII
|April 15, 2024
概括
新辅助化疗免疫疗法增强非小细胞肺癌 (NSCLC) 患者的CD8+T细胞活性. 基线T细胞和Treg频率可以预测治疗反应,增加IL-2和CXCL10表明更好的结果.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 翻译医学是一种翻译医学.
背景情况:
- 新辅助药用化疗阻断PD-1对可切除的非小细胞肺癌 (NSCLC) 有希望.
- 病理反应的潜在免疫机制和预测生物标志物仍然不清楚.
研究的目的:
- 研究NSCLC中新辅助化疗免疫治疗的免疫机制.
- 为了确定预测新辅助治疗病理反应的生物标志物.
主要方法:
- 流细胞计和mRNA-seq用于分析CD8+T细胞和Treg亚组,细胞因子概况和NSCLC患者接受新辅助化疗免疫治疗的血液样本中的基因表达的动态变化.
- 多重体免疫光分析了瘤组织中透的T细胞子集.
主要成果:
- 分析了42名NSCLC患者,其中45%实现了病理完整反应 (pCR).
- 在PCR和非PCR组之间,CD137+ CD8+ T细胞,PD-1+ Ki-67+ CD8+ T细胞和Tregs的治疗前频率有显著差异.
- 新辅助化学免疫疗法增加了CD8+T细胞的增殖和激活,特别是在pCR患者中,伴随着IL-2和CXCL10水平的升高.
结论:
- 新辅助化疗免疫疗法促进了繁殖和活跃的CD8+T细胞概况.
- CD137+ CD8+ T细胞,PD-1+ Ki-67+ CD8+ T细胞和Tregs的基线频率可以预测NSCLC的治疗反应.
- 增加IL-2和CXCL10水平与增强的细胞毒性T细胞活性和更好的治疗结果相关.
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