探索Aspergillus wentii的潜力:二次代谢产物和生物特性
Bayan E Ainousah1, Sabrin R M Ibrahim2,3, Abdulrahim A Alzain4
1Department of Pharmaceutical Sciences, Faculty of Pharmacy, Umm Al-Qura University, 21955, Makkah, Saudi Arabia.
Archives of microbiology
|April 15, 2024
概括
本综述详细介绍了来自Aspergillus wentii的生物活性二次代谢产物,确定了97种化合物. 这些发现突出了真菌的作用.
科学领域:
- 菌类学 菌类学是指菌类学.
- 自然产品 化学 化学
- 药理学是指药理学,即药理学是指药理学.
背景情况:
- ,特别是阿斯伯吉勒斯菌种,是生物活性二次代谢物的重要来源.
- 这些代谢物具有强大的生物活性和新的结构,使它们对药物发现有价值.
- Aspergillus wentii是一种具有重要的工业,医药和农业相关性的世界性物种.
研究的目的:
- 综合审查由Aspergillus wentii Wehmer产生的二次代谢产物.
- 要总结这些化合物和真菌的酶的生物活性,生物合成和应用.
- 为未来研究Aspergillus wentii的药理和生物技术潜力提供参考.
主要方法:
- 1951年至2023年11月的科学出版物的文献综述.
- 对于Aspergillus wentii.报告的二次代谢物的识别和分类.
- 收集有关生物活性,生物合成途径和应用的数据.
主要成果:
- 在Aspergillus wentii.中,共有97种化合物被确定.
- 这些化合物包括各种各样的类别,如化合物, terpenoids, antraquinones, xanthones, benzamides 和 glucans.
- 报告的生物活性和生物合成途径被总结,以及真菌和酶应用.
结论:
- 阿斯伯吉洛斯温蒂是一种结构多样化的二次代谢产物的丰富来源,具有显著的生物活性.
- 该审查巩固了现有知识,促进了对其制药和生物技术应用的进一步探索.
- 这种真菌代表了新药开发和工业酶发现的有希望的储备.
关键词:
阿斯珀吉勒斯温蒂伊 (Aspergillus wentii) 是一个植物.菌的真菌是一种.健康和福祉健康和福祉陆地上的生命.可持续发展目标 (SDGs) 是一个可持续发展目标.二次代谢产物二次代谢产物更多相关视频
09:21Inhibition of Aspergillus flavus Growth and Aflatoxin Production in Transgenic Maize Expressing the α-amylase Inhibitor from Lablab purpureus L.
Published on: February 15, 2019
10.5K
10:33Isolation of Culturable Yeasts and Molds from Soils to Investigate Fungal Population Structure
Published on: May 27, 2022
5.5K
相关概念视频
Overview of Fungi
2.4K
Fungi are a diverse group of eukaryotes more closely related to animals than other eukaryotes. Fungal cell walls comprise chitin, a polysaccharide that provides structural strength, and glucans, which contribute to flexibility and integrity. Other polysaccharides, such as mannans and galactosans, may supplement or replace chitin in some fungi. These adaptations, along with their preference for acidic environments and tolerance for high osmotic pressure, enable fungi to thrive in various...
2.4K
Fungal Phylum Ascomycota
2.4K
Phylum Ascomycota, a major division within the subkingdom Dikarya, comprises a diverse range of fungal species, including both unicellular yeasts and filamentous molds such as Aspergillus and Penicillium. These fungi thrive in a variety of habitats, from aquatic ecosystems to terrestrial environments, playing crucial ecological and economic roles.Morphology and ReproductionThe defining characteristic of Ascomycetes, commonly referred to as sac fungi, is the ascus—a sac-like structure that...
2.4K
Fungal Phylum Basidiomycota
2.1K
Basidiomycota is a diverse phylum of fungi that includes ecologically significant decomposers such as white rot fungi, symbionts like mycorrhizal fungi, plant pathogens such as rusts and smuts, and edible species like Agaricus bisporus (the common button mushroom). These fungi play crucial roles in nutrient cycling, symbiotic relationships, and even human health. Their defining feature is the basidium, a microscopic club-shaped structure responsible for producing basidiospores.Fruiting Bodies...
2.1K
Antifungal Agents
118
Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...
118
