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系统性轻链氨基粉症的最小残留疾病:系统性审查和元分析

Xuefeng Li1, Yan Yu1, Hongbin Yu1

  • 1Department of Hematology and Institute of Hematology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Journal of cancer research and clinical oncology
|April 15, 2024
PubMed
概括

在AL氨基粉症中,最小残留疾病 (MRD) 的消极性预测了更好的心脏和脏反应,并改善了无进展的生存率. 然而,它并没有显著影响患者的整体存活率.

关键词:
在AL氨基粉症症.最少残留疾病的最小残留疾病.总体生存率 总体生存率没有进展的生存率.系统性轻链氨基粉症.

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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