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乳酸/酸盐比率的变化可能导致雄性大鼠与衰老相关的肠壁功能障碍

Berrin Papila¹, Ayla Karimova², Ilhan Onaran²

¹Department of General Surgery, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Cerrahpasa, Fatih, 34098, Istanbul, Turkey. papilaberrin@yahoo.com.

|April 15, 2024

概括

老龄化增加了老鼠的肠道透性,但不是由于常见的线粒体DNA缺失. 改变的葡萄糖分解,而不是线粒体功能障碍,似乎将衰老与较弱的肠道屏障联系起来.

科学领域:

老年学是指老年学的学科.
胃肠病学胃肠病学
线粒体生物学线粒体生物学

背景情况:

衰老与肠道透性增加和潜在的线粒体功能障碍有关.
一种特定的线粒体DNA (mtDNA) 删除 (4834-bp) 已与与年龄相关的代谢干扰有关.

研究的目的:

在大鼠中调查常见的mtDNA删除,线粒体功能,肠道透性和衰老之间的关联.
探索改变新陈代谢在与年龄相关的肠道屏障变化的作用.

主要方法:

来自年轻 (4个月大) 和老年 (24个月大) 鼠的肠道组织和血清的比较.
分析mtDNA删除和拷贝数,线粒体膜潜力,ATP,乳酸和酸盐水平.
测量血清佐努林和肠脂肪酸结合蛋白 (I-FABP) 作为肠道透性的标志物.

主要成果:

老老鼠的血清佐努林和I-FABP水平显著上升,这表明肠道透性增加.
在常见的mtDNA删除水平,mtDNA复制数或年龄组之间的ATP水平之间没有发现显著差异.
线粒体膜潜力相似,但老老鼠的乳酸/酸盐比率明显较低,表明糖分分解能力发生了变化.

结论:

常见的mtDNA 4834-bp删除似乎不是与年龄相关的肠道透性的原因.
由较低的乳酸盐/酸盐比率表明的改变的糖溶性容量,更有可能是将衰老与增加的肠道透性联系在一起的因素.
代谢平衡,特别是糖解和线粒体功能之间的平衡,对于在衰老期间保持肠道屏障完整性至关重要.

关键词:

衰老的衰老衰老的衰老常见的删除常见的删除葡萄糖溶解是什么? 葡萄糖溶解肠道的透性肠道的透性乳酸盐是一种乳酸盐.线粒体中的线粒体.

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