中性细胞外细胞陷 (NETs) 与2型糖尿病和糖尿病足相关的截肢有关:一项前性队列研究
Irshat Ibrahim1, Yilimire Nuermaimaiti2, Gulijianaiti Maimaituxun3
1Department of General Surgery, The First People's Hospital of Kashi Prefecture, Kashi, 844000, China.
概括
糖尿病足 (DFU) 患者中中性粒细胞外陷 (NET) 的升高预测截肢风险. 较高的NET水平表明截肢的可能性更高,有助于临床评估.
科学领域:
- 生物医学科学 生物医学科学
- 临床研究 临床研究
- 糖尿病学 糖尿病学
背景情况:
- 糖尿病足 (DFU) 是全球下肢截肢的主要原因.
- 糖尿病患病率上升需要更好的DFU评估和治疗策略.
- 中性粒细胞外细胞陷 (NETs) 参与了DFU的发病和受损的愈合.
研究的目的:
- 研究血清NET水平在预测DFU相关截肢时的预后价值.
- 评估糖尿病患者的NET水平与截肢风险之间的关联.
主要方法:
- 用三个队列进行前性研究:DFU患者 (n=200),新诊断的T2DM患者 (n=42) 和健康的捐赠者 (n=38).
- 在所有参与者身上测量了血清NET水平.
- 使用考克斯回归和ROC曲线分析了DFU相关截肢的预后值.
主要成果:
- 与T2DM患者和健康捐赠者相比,DFU患者的血清NET水平显著更高.
- 血清NET水平,糖尿病脚手术史和瓦格纳等级被确定为截肢的独立风险因素.
- 高血清NET水平与DFU患者截肢的可能性显著增加有关 (HR=0.19,P<0.01).
结论:
- 血清NET水平升高是DFU相关截肢风险的有价值,可访问的预后标志物.
- NET水平可以帮助医疗保健提供者评估DFU患者的截肢风险.
- 需要进一步的研究来阐明连接NET和DFU结果的潜在机制.
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