相关实验视频

Updated: Jun 8, 2026

Determination of High-affinity Antibody-antigen Binding Kinetics Using Four Biosensor Platforms
15:27

Determination of High-affinity Antibody-antigen Binding Kinetics Using Four Biosensor Platforms

Published on: April 17, 2017

20.8K

使用三种生物物理方法对基准G4探针和G4临床药物的系统评估:快速评估G4结合亲缘关系的指南

E Laigre1,2, H Bonnet3, C Beauvineau1,2

  • 1CNRS UMR9187, INSERM U1196, Institut Curie, PSL Research University, F-91405, Orsay, France.

Chembiochem : a European journal of chemical biology
|April 15, 2024
PubMed
概括

DC3是最强大的G-四复数DNA (G4) 结合剂,在各种G4序列中表现优于其他配体. 这项研究系统地对G4联体进行排名,有助于对针对G4结构的研究和治疗应用进行选择.

关键词:
在FRET炼过程中,在G-四重复合体连接体中.在 G4-FID 中.具有G4结合的亲和力.在SPR中使用SPR.

更多相关视频

In Vivo EPR Assessment of pH, pO2, Redox Status, and Concentrations of Phosphate and Glutathione in the Tumor Microenvironment10:46

In Vivo EPR Assessment of pH, pO2, Redox Status, and Concentrations of Phosphate and Glutathione in the Tumor Microenvironment

Published on: March 16, 2018

8.3K
Using a Chemical Biopsy for Graft Quality Assessment05:00

Using a Chemical Biopsy for Graft Quality Assessment

Published on: June 17, 2020

5.2K

相关概念视频

The Equilibrium Binding Constant and Binding Strength02:18

The Equilibrium Binding Constant and Binding Strength

The equilibrium binding constant (Kb) quantifies the strength of a protein-ligand interaction. Kb can be calculated as follows when the reaction is at equilibrium:
Protein-Drug Binding: Determination Methods01:22

Protein-Drug Binding: Determination Methods

Determining protein-drug binding can be achieved through indirect and direct methods, each providing valuable insights into the interaction between proteins and drugs.
Indirect methods involve isolating the bound drug from its free form in biological samples such as blood, serum, or plasma. These techniques aim to measure the percentage of drugs bound to proteins. Equilibrium dialysis is a commonly used method where the free drug concentration at equilibrium is measured by separating the bound...
Measurement of Bioavailability: Pharmacodynamic Methods01:20

Measurement of Bioavailability: Pharmacodynamic Methods

Pharmacodynamic methods provide insights into a drug's effects on physiological processes over time and play a crucial role in understanding bioavailability and therapeutic efficacy. These methods can be broadly classified into acute pharmacological and therapeutic response approaches, each with distinct mechanisms and applications.The acute pharmacological response method directly correlates a drug's physiological effects, such as ECG or pupil diameter changes, to its time course in the body.