住院COVID-19患者的神经诊断与不良结果相关:一项跨国队列研究
Meghan R Hutch1, Jiyeon Son2, Trang T Le3
1Department of Preventive Medicine, Northwestern University, Chicago, Illinois, United States of America.
PLOS digital health
|April 15, 2024
概括
在住院期间患有中枢神经系统 (CNS) 或外周神经系统 (PNS) 疾病的COVID-19患者面临更糟糕的结果. 中枢神经系统的参与增加了成人和儿童的死亡风险,突出显示了COVID-19患者神经监测的必要性.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 神经学表现在COVID-19中很常见,但在大规模多样化的人群中了解得很少.
- 区分中枢神经系统 (CNS) 和外周神经系统 (PNS) 的参与对于理解患者的结果至关重要.
研究的目的:
- 评估住院COVID-19患者长时间住院和死亡的风险,同时涉及中枢神经系统或脑后神经系统.
- 为了比较患有神经疾病的患者和没有神经疾病 (NNC) 的患者之间的结果.
主要方法:
- 利用7个国家的21个医疗保健系统的联合跨国网络,策划电子健康记录.
- 适用联合学习和考克斯成人的比例危险模型;报告了儿童的描述性统计数据.
- 分析了106,229名住院COVID-19患者的数据 (2020年1月至2021年10月).
主要成果:
- 14%的成年人和3%的儿童有中枢神经系统或脑后神经系统的诊断.
- 中枢神经系统受影响的成年人经历了更长的住院时间 (11天而不是6天) 和增加的死亡风险 (HR=1.78).
- 与NNC相比,中枢神经系统受影响的儿童的死亡率更高 (6%比1%高).
结论:
- 在急性COVID-19住院期间同时出现的中枢神经系统表现与显著增加不良临床结果的风险有关.
- 联合信息学框架对全球临床发现,特别是传染病有价值.
- 神经监测对于住院COVID-19患者至关重要,特别是那些中枢神经系统参与的人.
相关概念视频
Pneumonia I: Introduction
230
Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
230
Alzheimer's Disease: Overview
468
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
468
Neural Regulation
39.4K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.4K
Pneumonia IV: Management
324
The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
324
Pneumonia III: Complications and Assessment
205
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
205
Documentation of Nursing Diagnosis
1.2K
The nurse documents nursing diagnoses and enters them into the patient record. The identified patient's nursing diagnosis is either written out with a plan of care or entered into the electronic health record.
In some settings, data-driven computerized decision support systems are in place, allowing for more accurate nursing diagnoses. The database within one of these systems includes diagnostic labels defining characteristics, activities, and indicators for nursing. A nurse enters...
In some settings, data-driven computerized decision support systems are in place, allowing for more accurate nursing diagnoses. The database within one of these systems includes diagnostic labels defining characteristics, activities, and indicators for nursing. A nurse enters...
1.2K


