氧化和病毒感染:抗病毒疗法和平台的最新发展
Mark R Garren1, Morgan Ashcraft1,2, Yun Qian1
1School of Chemical, Materials, and Biochemical Engineering, College of Engineering, University of Georgia, Athens, GA, USA.
Applied materials today
|April 15, 2024
概括
氧化 (NO) 显示出作为抗病毒剂的前景. 本综述探讨了用于对抗病毒感染和传播的无释放材料,强调了未来的治疗潜力.
科学领域:
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
- 材料科学 材料科学 材料科学
背景情况:
- 氧化 (NO) 是一种关键的气传递物,参与抗病毒和细菌感染的天生的免疫力.
- 通过氧化合成酶的NO上调抑制病毒复制,这表明抗病毒疗法的潜力.
- 呼吸道病毒流行病的增加需要广泛的治疗平台和材料来制传播.
研究的目的:
- 审查最近基于NO的抗病毒疗法的进展,包括气体NO,前期药物和捐赠化合物.
- 讨论使用NO作为抗病毒剂的局限性和挑战.
- 为下一代抗病毒平台设计无释放材料概述未来的方向.
主要方法:
- 文献综述最近的NO捐赠化合物发展及其纳入支架和基板的情况.
- 对NO在宿主防御病毒感染中的作用的分析.
- 探索用于医疗器械应用和感染控制的无释放材料.
主要成果:
- 在材料中集成的稳定NO供体化合物为持续的NO释放提供了一种新方法.
- 现有的研究在很大程度上忽视了用于减少病毒传播和治疗呼吸道感染的NO释放支架.
- NO显示出作为广泛的抗病毒剂的潜力,尽管存在局限性.
结论:
- 不释放NO的材料代表了开发新型抗病毒疗法和预防策略的有希望的前沿.
- 需要进一步的研究来克服NO的局限性,并优化材料设计以实现有效的抗病毒应用.
- 将NO释放技术集成到医疗器械和治疗平台中可以增强宿主防御并减少病毒传播.
关键词:
ACE 是一种血管酶转化酶.AP1,激活蛋白1 激活蛋白1 激活蛋白1在 COVID-19 疫情中,COVID-19,冠状病毒疾病 2019 年ECMO,体外膜氧化,FDA,美国食品和药物管理局.GNSO,S-亚酸氨酸,S-亚酸氨酸H1N1,流感A病毒亚型H1N1病毒.HI,东道主免疫学艾滋病毒,人类免疫缺陷病毒.人类乳头瘤病毒 (HPV),人类乳头瘤病毒.在HSV,简单疹病毒.输入/输出,肺缺血-再输血.IC50,抑制度 50 抑制度 50 抑制度IFN,干扰素 干扰素IFNγ,干扰素马γ,干扰素马γ.IKK,核因子卡帕B激酶的抑制剂.IRF-1,干扰子调节因素1 干扰子调节因素1吸入治疗是一种吸入疗法.医学术语:ARDS,急性呼吸道应急综合征NF-κB,激活B细胞的核因子卡帕光链增强剂.没有,氧化,氧化.NOS,一氧化合成酶,一氧化合成酶.氧化和相关化合物:eNOS/NOS 3,内皮氧化合成酶.氧化氧化是什么?其他:DNA,脱氧核糖核酸.P38-MAPK,P38中位素激活蛋白激酶,P38中位素激活蛋白激酶.PAMP,病原体相关的分子模式.PCV2,猪圈病毒2型 猪圈病毒2型在PHT,肺高血压,肺高血压.PKR,蛋白质激酶R,蛋白质激酶R.RNA,核糖核酸,核糖核酸,核糖核酸,核糖核酸.RNI,反应性中间体.RSNO,S-nitrosothiol,S-nitrosothiol,S-nitrosothiol,S-nitrosothiol,S-nitrosothiol,S-nitrosothiol,S-nitrosothiol,S-nitrosothiol,S-nitrosothiol,S-nitrosothiol,S-nitrosothiol,S-nitrosothiol,S-nitrosothiol,S-nitrosothiol,S-nitrosothiol,S-nitrosothiol,S-nitrosothiol,S-nitrosothiol,S-nitrosothiol,S-nitrosothiol,S-nitrosothiol,S-nitrosothiol,S-nitrosothiol,S-nitrosothiol,S-nitrosothiol,S-nitrosothiol,S这是SARS,严重急性呼吸道综合征.SARS-CoV-2,严重急性呼吸系统综合征冠状病毒2SNAP,S-nitroso-N-乙-青氨酸,S-nitroso-N-乙-青氨酸,S-nitroso-N-乙-青氨酸,S-nitroso-N-乙-青氨酸,S-nitroso-N-acetyl-penicillamine,S-nitroso-N-acetyl-penicillamine,S-nitroso-N-acetyl-penicillamine,S-nitroso-N-acetyl-penicillamine,S-nitroso-N-acetyl-penicillamine,S-nitroso-N-acetyl-penicillamine,S-nitroso-N-acetyl-penicillamine,S-nitroso-N-acetyl-penicillamine,S-nitroso-N-N-acetyl-penicillamine,S-N-N-acetyl-penicillamine,S-N-N-N-acetyl-penicil-penicil-STAT-1,信号传感器和转录的激活器 1 1严重的急性呼吸道应急症TAK1,转化生长因子β激活激酶-1的转化生长因子.TLR,类似收费的受体.VAP,呼吸机相关的肺炎.病毒感染是一种病毒感染.病毒:CVB3,Coxsackie病毒 病毒dsRNA,双链 (病毒) 核糖核酸.gNO,气态氧化.iNOS/NOS 2,可以诱导的氧化合成酶.mtALDH,是线粒体的化物脱酶.nNOS/NOS 1,神经元中的氧化合成酶.
相关概念视频
01:28Nitric Oxide Signaling Pathway
5.0K
Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure...
5.0K
01:29Immune Response Against Viral Pathogens
777
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
777
01:16Antianginal Drugs: Nitrates and β-Blockers
579
In cardiovascular health, antianginal drugs combat angina pectoris — a condition marked by chest pain owing to diminished blood flow to the heart.
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....
579
02:49Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K