在患有COVID-19感染的重症患者中进行增强型血栓预防
R L Kummer1, K A Considine2, M A Rankin2
1From the Departments of Medicine, Hennepin County Medical Center, USA.
Thrombosis update
|April 15, 2024
概括
在重症COVID-19患者的增强型血栓预防有效地预防了血栓栓塞事件. 这种强度增加的方法显示严重出血率较低,这表明在严重的SARS-CoV-2感染中管理凝血异常的安全概况有利.
科学领域:
- 关键护理医学 关键护理医学
- 血液学 血液学 血液学
- 传染病 传染病 传染病
背景情况:
- 严重的SARS-CoV-2感染与异常凝血和血栓栓塞的风险增加有关.
- 对于COVID-19患者的最佳血栓预防方案仍然不确定,平衡血栓形成的预防和出血风险.
研究的目的:
- 评估COVID-19的医疗重症监护室 (MICU) 患者增强型血栓预防的疗效和安全性.
主要方法:
- 对120名进入MICU的COVID-19患者进行了回顾性队列分析.
- 增强型血栓预防使用了高于标准剂量的埃诺沙巴林或未分离的肝素 (不包括ECMO或慢性抗凝剂患者).
主要成果:
- 只有5% (6/120) 的患者患有血栓塞栓症 (肺栓塞,深静脉血栓,动脉栓塞).
- 四名患者在治疗抗凝固药时经历了重大出血事件.
结论:
- 增强型血栓预防似乎可以有效地预防重症COVID-19患者的显著血栓栓塞事件.
- 这种方法与严重出血的风险较低有关,这表明潜在的有利的风险-收益概况.
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