在针对SARS-Cov-2接种疫苗的健康人群中,没有参数变化,也没有凝血激活
Flora Peyvandi1,2, Erica Scalambrino1, Marigrazia Clerici1
1Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione Luigi Villa, Milan, Italy.
Thrombosis update
|April 15, 2024
概括
这项研究发现,在瑞-生物科技COVID-19疫苗接种后,凝血参数或激活迹象没有显著变化. 这些发现解决了人们对SARS-CoV-2疫苗接种后发生的血栓事件的担忧.
科学领域:
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 接种SARS-CoV-2疫苗后发生的血栓事件引起了人们的担忧.
- 了解疫苗接种后的凝血参数变化至关重要.
研究的目的:
- 调查SARS-CoV-2疫苗接种后凝血参数的变化.
- 评估疫苗接种后的血栓生成和抗血小板因子4 (aPF4) 水平.
主要方法:
- 凝血参数,血栓生成 (ex-vivo和in-vivo) 和aPF4在30名受试者中进行了测量.
- 在瑞-生物科技疫苗的第一剂和第二剂接种之前和之后的多个时间点进行了测量.
主要成果:
- 在大多数凝血参数中没有观察到临床相关的变化.
- 血小板数量略有增加和血栓生成标记物 (F1.2,ETP,ETP-TM比率) 略有下降.
- 抗血小板因子4 (aPF4) 在几乎所有受试者中都是负的.
结论:
- 瑞-生物科技疫苗没有引起凝血参数的显著修改.
- 疫苗接种后没有检测到凝血激活的生物化学证据.
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