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通过胸部计算机断层扫描评估CFTR调节器治疗对身体组成的影响:一项后续研究

Víctor Navas-Moreno¹, Fernando Sebastian-Valles¹, Víctor Rodríguez-Laval²

¹Department of Endocrinology and Nutrition, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria de La Princesa, Madrid, Spain.

Nutrition (Burbank, Los Angeles County, Calif.)

|April 15, 2024

概括

囊性纤维化跨膜导电调节器 (CFTR) 调节器治疗改善肺功能,增加体质,主要是脂肪质量,在CF患者. 计算机断层扫描 (CT) 有效地评估这些身体成分变化.

科学领域:

医疗成像医学成像
肺部病理学肺部病理学
身体组成分析身体成分分析

背景情况:

用CFTR调节剂治疗囊性纤维化 (CF),显著改善肺功能 (FEV1) 和临床结果.
CFTR调节器治疗与体重增加有关,需要评估身体组成的变化.

研究的目的:

用计算机断层扫描 (CT) 来评估CFTR调节器治疗对成年CF患者身体组成的影响.
为了比较CT衍生的身体组成与生物阻抗估计和临床/精神测量数据.

主要方法:

接受elexacaftor-tezacaftor-ivacaftor (ELX/TEZ/IVA) 治疗的成年CF患者接受了CT扫描以分析身体组成.
用开源软件分析CT数据,并与生物阻抗测量和临床参数进行比较.

主要成果:

脑电图扫描显示,治疗后的总体面积,总脂肪量,皮下脂肪,内脏脂肪和肌肉间脂肪显著增加.
非常低密度肌肉质量是唯一增加的肌肉部分,而较高的治疗前非常低密度肌肉与较差的FEV1改善有关.
CT衍生的脂肪质部分与生物阻抗有很好的相关性,正常密度的肌肉与相角有很好的相关性.

结论:

计算机断层扫描 (CT) 是评估CFTR调节器治疗的CF患者的身体组成变化的宝贵工具.
CFTR调节器治疗导致FEV1的改善和体重增加,主要是通过脂肪积累.

关键词:

身体组成身体组成在CFTR调制器.囊性纤维化症是什么营养状态营养状况

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