离子液体对生物效应的机制:从单细胞到多细胞生物
Ksenia S Egorova1, Alexey V Kibardin2, Alexandra V Posvyatenko1,2
1Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow 119991, Russia.
Chemical reviews
|April 15, 2024
概括
离子液体 (ILs) 在各种应用中表现有前途,但它们的生物相互作用尚未完全理解. 本综述详细介绍了IL毒性机制,包括细胞膜破坏和细胞亡,指导更安全的设计和使用.
科学领域:
- 绿色化学 绿色化学
- 毒理学 毒理学 毒理学
- 生物技术是生物技术.
背景情况:
- 离子液体 (ILs) 是多功能化合物,具有可调整的物理化学特性.
- 它们的应用正在扩大,但生物相互作用和毒性仍未得到充分探索.
- 了解IL对生命系统的影响对于安全应用至关重要.
研究的目的:
- 批判性地审查有关离子液体毒性机制的当前知识.
- 探索离子液体和生物系统之间的相互作用.
- 引导设计较少有毒的IL及其在医学和药物开发中的明智使用.
主要方法:
- 审查有关离子液体细胞毒性的现有文献.
- 对IL对细胞培养,生物分子和生物体的影响研究的分析.
- 检查IL诱导的细胞损伤的已知发现.
主要成果:
- 离子液体可以破坏细胞膜,诱导氧化应激,并触发细胞亡.
- 毒性与IL特性及其与细胞组件的相互作用相关.
- 目前对IL毒性的理解仍在发展.
结论:
- 需要进一步研究IL的分布,新陈代谢和在亚毒度的影响.
- 需要详细分析ILs对氧化应激和亡途径的影响.
- 这一审查为设计更安全的IL及其在各个领域的负责任应用提供了基础.
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