在非透析依赖慢性病患者的骨矿物质密度的变化与身体组成有关
Julia Montenegro1, Márcia Regina Simas Torres Klein2, Carla M Prado1
1Human Nutrition Research Unit, Department of Agricultural, Food and Nutritional Science, Division of Human Nutrition, University of Alberta, Edmonton, Alberta, Canada.
概括
瘦软组织 (LST) 损失与慢性病 (CKD) 患者的骨矿物质密度 (BMD) 降低有关. 这项纵向研究强调LST作为非透析依赖性CKD (NDD-CKD) 骨髓质量损失的保护因素.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 慢性病 (CKD) 和低骨矿物密度 (BMD) 经常同时存在.
- 矿物代谢参数影响CKD中的BMD,但其他因素也参与其中.
- 非透析依赖性CKD (NDD-CKD) 患者经历了独特的生理变化.
研究的目的:
- 评估NDD-CKD患者的BMD及其决定因素的变化.
- 为了确定身体组成和BMD之间的纵向关联.
- 调查在早期CKD中导致BMD损失的因素.
主要方法:
- 对NDD-CKD患者进行了回顾性队列研究.
- 双能X射线吸收计测试身体组成 (瘦软组织[LST],脂肪质量) 和骨质量评估.
- 计算附录LST指数 (ALSTI) 和负载能力指数 (LCI).
主要成果:
- 在2.8年内,患者的LST,ALST和ALSTI都减少了, BMD下降和脂肪质量增加的趋势.
- 女人经历了BMD,ALST和ALSTI的显著减少.
- 基线LST,ALST和ALSTI是随访BMD状态的独立预测因素.
结论:
- NDD-CKD与有害的身体组成变化有关,特别是在女性身上,独立于体重.
- 这项研究是第一个纵向证据,证明LST在NDD-CKD中对BMD损失起着保护作用.
- 维持LST可能对保持NDD-CKD患者的骨健康至关重要.
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