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Updated: Jun 28, 2025

Author Spotlight: Elucidating the Pathways of TFH Cell Differentiation in Acute LCMV Challenges
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Author Spotlight: Elucidating the Pathways of TFH Cell Differentiation in Acute LCMV Challenges

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在常见的可变免疫缺陷中,ICOS主激素vopratelimab调节毛囊辅助T细胞并改善B细胞功能

Ali Sepahi1, Hsi-En Ho2, Prapti Vyas3

  • 1PharmaEssentia Innovation Research Center, Bedford, MA, United States; Concentra Biosciences, LLC, Cambridge, MA, United States.

Clinical immunology (Orlando, Fla.)
|April 15, 2024
PubMed
概括

常见的可变免疫缺陷 (CVID) 涉及B细胞成熟受损. 一种可诱导的T细胞共刺激剂 (ICOS) 激动剂,vopratelimab,恢复了T毛囊辅助细胞 (TFH) 和增强了B细胞功能,增加了CVID患者的免疫球蛋白产生.

关键词:
常见的可变免疫缺陷常见的可变免疫缺陷.毛囊辅助T细胞 毛囊辅助T细胞这就是ICOS ICOS.增加了血芽细胞的数量诱导性T细胞共刺激器产生IL-10和IL-4的过程.

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