基于网络药理学的Xing 9 ling药片糖果对酒精性肝病的机制
Xiaomei Zhao1, Qiong Qu1, Ying Zhang1
1Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China.
Analytical biochemistry
|April 15, 2024
概括
Xing 9 Ling平板糖果 (X9LTC) 通过向PTGS2,JUN和FOS来治疗酒精性肝病 (ALD). 网络药理学确定了关键途径,动物研究证实了X9LTC.
科学领域:
- 药理学 药理学是指药理学的学科.
- 肝病学 肝病学是一种肝病学.
- 计算生物学 计算生物学
背景情况:
- 酒精性肝病 (ALD) 构成了严重的健康负担.
- 对ALD的Xing 9 Ling糖果片 (X9LTC) 的治疗机制基本上是未知的.
- 了解X9LTC的分子点对于优化ALD治疗至关重要.
研究的目的:
- 通过网络药理学阐明X9LTC的作用机制并确定用于治疗ALD的X9LTC分子标.
- 通过分子对接和动物实验验证预测的目标和途径.
主要方法:
- 对X9LTC活性成分和标的网络药理学分析.
- 高性能液态色谱 (HPLC) 用于成分识别.
- 蛋白质与蛋白质相互作用网络的构建和核心目标的识别.
- 路径丰富分析 (KEGG,GO).
- 分子对接模拟. 分子对接模拟.
- 使用ALD小鼠模型进行体内研究.
主要成果:
- 确定了X9LTC.的35个活性成分和311个潜在目标.
- PTGS2,JUN和FOS被确定为核心目标.
- 丰富分析突出了化学致癌受体激活,IL-17和TNF信号通路.
- 分子对接证实了化合物和标之间良好的结合亲缘关系.
- 在ALD小鼠中,X9LTC治疗降低了血清ALT,AST和TG水平,减轻了肝病变,降低了PTGS2,JUN和FOS的表达.
结论:
- 通过对PTGS2,JUN和FOS的调节,X9LTC证明了ALD的治疗潜力.
- 网络药理学为了解X9LTC在ALD中的机制提供了一个强大的框架.
- 这项研究为进一步研究X9LTC作为ALD治疗剂奠定了基础.
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