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用超临界抗溶剂 (SAS) 工艺在类似复合物质的弹性质中封装乙醇胺,用于青光眼治疗

Reinaldo Vallejo¹, Daniela Quinteros², Javier Gutiérrez³

¹Smart Devices for Nano Medicine Group, Unidad Excelencia Instituto de BioMedicina y Genética Molecular (IBGM) de Valladolid, University of Valladolid and CSIC, Valladolid, Spain; BioEcoUVa, Research Institute on Bioeconomy, High Pressure Process Group, University of Valladolid, Department of Chemical Engineering and Environmental Technology, Escuela de Ingenierías Industriales, Sede Mergelina, 47011 Valladolid, Spain.

International journal of pharmaceutics

|April 15, 2024

概括

这项研究开发了一种新的药物输送系统,用于治疗眼,使用类似弹性素的重组聚合物和超临界的CO2. 该系统有效地提供了阿扎胺,显示了改善青光眼治疗和减少失明的前景.

科学领域:

生物材料科学生物材料科学
眼科医生眼科眼科
药物输送系统药物输送系统

背景情况:

玻璃眼是全球导致失明的主要原因,需要先进的治疗策略.
由于药物溶解性和透性问题,目前的治疗方法面临挑战.
新型药物输送系统对于提高治疗疗效至关重要.

研究的目的:

开发和描述一种新型的控制释放系统,用于治疗青光眼的乙醇胺 (AZM).
用超临界抗溶剂 (SAS) 技术将AZM封装在类似弹性质的重组聚合物 (ELR) 中.
评估开发的纳米粒子的物理化学性质,眼睛透,安全性和体内有效性.

主要方法:

通过超临界抗溶剂 (SAS) 技术将乙醇胺 (AZM) 封装成两性弹性类似重组酶 (ELR).
使用扫描电子显微镜 (SEM),传输电子显微镜 (TEM) 和原子力显微镜 (AFM) 进行微/纳米粒子的表征.
在高血压子中评估纳米粒子稳定性 (泽塔潜力),横角膜透,眼部刺激和眼内压力 (IOP) 降低.

主要成果:

在ELR中成功封装AZM,产量高达62%,形成球形微粒,分解为~42nm纳米粒子.
稳定,非聚合的纳米粒子,在30天内具有-33mV的泽塔潜力.
在子中增强了透视角膜 (高达30%的增加) 和显著的IOP降低,没有观察到眼部刺激.

结论:

通过SAS技术生产的基于ELR的纳米颗粒提供了一个有前途的,安全和有效的药物输送系统,用于玻璃眼.
这种方法提高了阿扎胺的生物可用性和治疗结果,可能改善了对玻璃眼的临床治疗.
再组合生物聚合物和高压技术的组合具有促进青光眼治疗的巨大潜力.

关键词:

乙醇胺的使用方法弹性类重组聚合物.纳米颗粒纳米颗粒眼科药物输送是眼科药物输送.超临界抗溶剂超临界抗溶剂

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