卵泡甲状腺癌中的大头骨转移:全面的病例介绍和系统审查
Gianluca Scalia1, Massimiliano Porzio2, Roberta Costanzo2
1Department of Head and Neck Surgery, Neurosurgery Unit, Garibaldi Hospital, Catania, Italy.
概括
卵泡性甲状腺癌 (FTC) 的头骨转移很罕见,但很严重. 本综述强调了各种症状,诊断成像和手术,放射和向治疗等治疗方法,预后不好,但可能改善结果.
科学领域:
- 在瘤学瘤学.
- 神经外科 神经外科
- 放射学 放射学是一门学科.
背景情况:
- 卵泡性甲状腺癌 (FTC) 的头骨转移不常见,但显著,可能导致疼痛和神经问题.
- 由于一些患者的无症状表现,早期检测具有挑战性.
研究的目的:
- 系统地审查FTC中关于大头骨转移的文献.
- 分析这些罕见转移的临床表现,诊断,治疗和结果.
主要方法:
- 系统的文献审查遵循PRISMA指导方针.
- 分析了15项涉及20名患有FTC头骨转移的患者的研究.
- 对临床,诊断,治疗和预后因素的数据综合.
主要成果:
- 主要症状包括局部疼痛 (70%) 和头痛.
- CT和MRI对于诊断至关重要;手术可在30-50%的患者中进行部分/完全切除.
- 放射治疗 (EBRT,SRS) 在70-80%的患者中实现局部控制;TKIs在45%的患者中稳定/逆转疾病.
结论:
- 包括手术,放射治疗和全身疗法在内的综合管理是必不可少的.
- 对于标准化指导方针,分子分析和像免疫疗法这样的新疗法,需要进一步的研究.
- 改善FTC头骨转移的结果需要持续调查和量身定制的治疗策略.
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