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Updated: Jun 28, 2025

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
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Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Published on: September 21, 2017

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一种新型的短暂受体潜力C3/C6选择性激活剂诱导细胞吸收反感性寡核酸

Hiroto Kohashi1, Ryu Nagata1, Yusuke Tamenori2

  • 1Graduate School of Pharmaceutical Sciences, Osaka University, Osaka 565-0871, Japan.

Nucleic acids research
|April 15, 2024
PubMed
概括

一种新的TRPC激活剂,L687,显著增强细胞对反感性寡核酸 (ASOs) 的吸收,提高其治疗潜力. 这一发现为ASO药物递送系统提供了新的策略.

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Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
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Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
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RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
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