相关实验视频
Updated: Jun 28, 2025
08:43
OLIgo Mass Profiling OLIMP of Extracellular Polysaccharides
Published on: June 20, 2010
13.7K
[从药用植物资源中获得的多糖的相对分子量与疗效之间的相关性分析和前景]
An-Ni Yao1, Yan Tang1, Da-Ying Luo1
1National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Jiangsu Province Key Laboratory of High Technology Research, Nanjing University of Chinese Medicine Nanjing 210023, China.
概括
药用植物多糖体根据其分子量表现出不同的生物活性. 定制多糖体大小可以提高它们对免疫,抗氧化和代谢健康的治疗潜力.
科学领域:
- 植物化学 植物化学
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 多糖是来自药用植物的复杂聚合物,具有多样化的结构和分子量.
- 这些多糖的生物活性与它们的分子量密切相关.
- 了解这种关系对于优化其治疗潜力至关重要.
研究的目的:
- 审查制备和检测不同分子量药用植物多糖的方法.
- 分析多糖的分子量与它们的生物疗效之间的相关性.
- 为了指导多糖的精确开发,以提高生物活性和应用价值.
主要方法:
- 对多糖的制备和检测技术的文献综述.
- 综合和分析现有关于多糖的有效性与分子重量的现有数据.
- 基于分子量范围的多糖类的分类:大 (>100 kDa),中等 (10-100 kDa) 和小 (<10 kDa).
主要成果:
- 大分子量多糖 (>100 kDa) 主要参与免疫调节.
- 中等分子量多糖 (10-100 kDa) 在免疫调节和肝脏保护方面表现出有效性.
- 小分子量多糖 (<10kDa) 是抗氧化剂,肠道微生物群调节,血糖/脂质控制,抗疲劳和神经保护的关键.
结论:
- 药用植物多糖的有效性受到分子重量的显著影响.
- 基于分子重量的有针对性的开发可以增强生物活性和治疗应用.
- 精确的分子量控制为优化植物性多糖的使用提供了一个有希望的策略.
更多相关视频
相关概念视频
01:10Polymers: Molecular Weight Distribution
3.4K
For any given polymer, the weight average molecular weight (Mw) is higher than, if not equal to, the number average molecular weight (Mn). The only situation in which the weight average molecular weight and the number average molecular weight are equal is when a polymer consists only of chains with equal molecular weight. However, this never happens in a synthetic polymer, since it is difficult to control the polymerization process up to a molecular level with accuracy to a hundred percent.
3.4K
01:01Polymers: Defining Molecular Weight
2.9K
Unlike small molecules with definite molecular weights, polymers are a mixture of individual polymer chains of varying lengths, each with a unique molecular weight. So, the molecular weight of a polymer is expressed as an average value based on the average size of the polymer chains. The two most common forms of averages used for polymers are the number average molecular weight and weight average molecular weight.
The number average molecular weight (Mn) is the summation of the number...
The number average molecular weight (Mn) is the summation of the number...
2.9K
01:08Molecular Weight of Step-Growth Polymers
2.2K
Step growth polymerization involves bi or multifunctional monomers. Bifunctional monomers react to form linear step growth polymers, whereas multifunctional monomers react to form non-linear or branched polymers.
As the step-growth polymerization involves step-wise condensation of monomers, the molecular weight also builds up eventually. Consequently, high molecular weight polymers are obtained at the late stages of the polymerization, where 99% of monomers have been consumed.
The extent of the...
As the step-growth polymerization involves step-wise condensation of monomers, the molecular weight also builds up eventually. Consequently, high molecular weight polymers are obtained at the late stages of the polymerization, where 99% of monomers have been consumed.
The extent of the...
2.2K