关于Hcy和Hs-CRP水平与双极性障碍和边缘性人格障碍患者认知功能之间的相关性研究
Chaomin Wang1, Lizhao Lv1, Bo Xin1
1Department of Psychiatry, The First Hospital of Hebei Medical University, 050031 Shijiazhuang, Hebei, China.
Actas espanolas de psiquiatria
|April 15, 2024
概括
高水平的同类氨酸 (Hcy) 和高灵敏性C反应蛋白 (hs-CRP) 与双极性障碍 (BD) 的认知障碍和边缘性人格障碍 (BPD) 的并发症有关. 这些标志物可以指导BD与BPD并发症的治疗.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 生物化学 生物化学
背景情况:
- 双极性障碍 (BD) 和边缘性人格障碍 (BPD) 经常伴有认知缺陷.
- 炎症标志物和homocysteine水平已与神经精神疾病有关.
研究的目的:
- 调查同类氨酸 (Hcy),高灵敏性C反应蛋白 (hs-CRP) 和BD患者的认知功能之间的相关性,特别是那些患有并发性BPD的患者.
- 评估这些生物标志物的临床意义在BD患者和没有BPD并发症.
主要方法:
- 从2022年1月到2022年12月对BD患者 (N=120) 的回顾性分析,分为并发症 (BD+BPD) 和非并发症 (仅BD) 组.
- 使用ELISA测量血清中的Hcy和hs-CRP水平.
- 临床症状通过汉密尔顿抑郁评分表 (HAMD) 和青年躁狂评分表 (YMRS) 进行评估.
- 使用可重复电池评估神经心理状态 (RBANS) 评估认知功能.
- 皮尔森相关性分析用于确定生物标志物,临床分数和认知功能之间的关系.
主要成果:
- 与非并发症组相比,并发症组的血清Hcy和hs-CRP水平,HAMD和YMRS得分显著更高 (p <0.05).
- 认知功能包括注意力,言语,视觉跨度,即时记忆和延迟记忆在并发症组显著受损 (p <0.05).
- 皮尔森相关性揭示了Hcy/hs-CRP和HAMD/YMRS得分之间的正相关性,以及共病组认知指标的负相关性 (p <0.05).
结论:
- 血清Hcy和hs-CRP水平升高与伴并发性BPD的BD患者的症状严重程度增加和认知障碍有关.
- 这些生物标志物可能在调节恶化认知功能障碍的炎症反应中发挥作用.
- Hcy和hs-CRP水平是认知功能障碍的重要指标,可以为BD与BPD并发性疾病的预防和治疗策略提供信息.
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