抗核抗体和核分子之间的独特相互作用在系统性红斑狼的发病过程中

David S Pisetsky1

  • 1Duke University Medical Center and Durham Veterans Administration Medical Center, Durham, North Carolina.

概括

系统性红斑狼 (SLE) 涉及到攻击细胞核组件的自身抗体. 这些抗体,特别是抗DNA,通过形成免疫综合体与死亡细胞的细胞外DNA和中性粒细胞外陷来驱动炎症和器官损伤.

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