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动态的域间转换调节了人类5,10-甲基基酸缩酶的全调节

Linnea K M Blomgren1, Melanie Huber1, Sabrina R Mackinnon2

  • 1Division of Metabolism and Children's Research Center, University Children's Hospital Zürich, University of Zürich, Zürich, CH-8032, Switzerland.

Nature communications
|April 15, 2024
PubMed
概括

人类的5,10-甲基基酸减少酶 (MTHFR) 使用独特的调节领域来控制其活性. 结构研究揭示了S-adenosyl-L-methionine (SAM) 的结合如何通过重组其结构来抑制MTHFR.

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