相关实验视频
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Noninvasive, High-throughput Determination of Sleep Duration in Rodents
Published on: April 18, 2018
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在微剂量后的晚上,LSD会增加睡眠时间
Nathan Allen1, Aron Jeremiah2, Robin Murphy3
1Faculty of Engineering, University of Auckland, Auckland, 1010, New Zealand. nathan.allen@auckland.ac.nz.
Translational psychiatry
|April 15, 2024
概括
在健康的男性中,微剂量10μg的lysergic acid diethylamide (LSD) 增加了大约24分钟的睡眠时间. 这项研究提供了对LSD微剂量的客观证据.
科学领域:
- 神经科学是一个神经科学.
- 心理药理学 心理药理学
- 睡眠科学 睡眠科学
背景情况:
- 迷幻药物的微剂量,比如lysergic acid diethylamide (LSD),是一个日益增长的生活方式趋势.
- 微剂量对睡眠生理学的影响仍然在很大程度上未经记录.
研究的目的:
- 研究亚幻觉性LSD微剂对健康成年人睡眠模式的影响.
- 在受控试验中使用可穿戴技术评估客观睡眠参数.
主要方法:
- 一个为期6周的随机,双盲,安慰剂控制的第一阶段试验.
- 80名健康的成年男性每三天自行服用10μg的LSD或安慰剂.
- 每晚使用商业睡眠追踪器监测睡眠和活动.
主要成果:
- 与安慰剂相比,LSD微剂量每晚平均增加了24.3分钟的睡眠时间.
- 没有观察到睡眠结构 (阶段) 或体力活动水平的显著变化.
- 由于其临床意义,观察到的睡眠时间增加不太可能是安慰剂效应.
结论:
- 亚幻觉性LSD微剂量显著改变健康男性的睡眠时间.
- 客观的睡眠测量显示了LSD微剂量的明显生理效应.
- 需要进一步的研究来了解这些睡眠修饰的机制和影响.
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